Merck, E8640-1MG, E-64d

Name: E-64d
Brand: Merck
SKU: E8640-1MG

Size:1 mg, (2S, 3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, EST, protease inhibitor

Available Catalog Numbers

E8640-1MG E8640-250UG

Catalog Number: E8640-1MG

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Category

Water Quality Test Strips

Pack Size1 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It has also been used as a protease inhibitor in free calcium physiological tyrode solution for perfusion into the isolated heart samples.
Biochem/physiol Actions
E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B, calpains 1 and 2. E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI) and Alzheimer′s disease (AD). It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.

Specifications

General

UNSPSC Code	12352202
PubChem Substance ID	24894681
NACRES	NA.77
Web Name Suffix Override	powder, ≥98% (TLC)
MDL number	MFCD00132883
SMILES string	CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI	1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key	SRVFFFJZQVENJC-IHRRRGAJSA-N
biological source	synthetic (organic)
assay	≥98% (TLC)
form	powder
solubility	methanol: water (1:1): 5 mg/mL, clear, colorless
storage temp.	−20°C
Quality Level	200
Gene Information	human ... CAPN1(823)

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