Description
General description
The glucagon-like peptides GLP-1 and GLP-2 are important gut hormones released from the small intestine upon nutrient ingestion. In circulation, GLP-2 is present in two molecular forms, GLP-2 (1-33) and GLP-2 (3-33). Similar to GLP-1, active form GLP-2 (1-33) is cleaved to inactive form GLP-2 (3-33) by protease DPPIV. GLP-2 has been shown to play important roles in the regulation of gastrointestinal functions (digestion, absorption, motility, epithelial growth, and blood flow) and bone resorption. Thus, GLP-2 or its analogs may have therapeutic potentials for the treatment of diseases such as Crohn’s disease and osteoporosis.
Application
Research Category
Metabolism
Research Sub Category
Osteoporosis
This assay requires 50 µl of rat or human samples and is performed at room temperature as a 4 hour assay. GLP-2 has also been detected in guinea pig, horse, porcine, and non-human primate samples.
Used to detect/quantify: GLP-2
Biochem/physiol Actions
Human GLP-2 1-33 100%
Human GLP-2 3-33 112%
Rat GLP-2 101%
Other Notes
Please contact Technical Service for linearity of dilution.
Disclaimer
For research use only. Not for use in diagnostic procedures.