Merck, F6627-5G, 5-Fluorouracil

Name: 5-Fluorouracil
Brand: Merck
SKU: F6627-5G

Size:5 g, 2, 4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2, 4(1H, 3H)-pyrimidinedione, ≥99% (HPLC), powder

Available Catalog Numbers

F6627-10G F6627-1G F6627-5G

Catalog Number: F6627-5G

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Category

Special Stains

Pack Size5 g

TagsClinical & Diagnostics Tissue Diagnostics Hematology Stains

CollectionsMerck Tissue Diagnostics – Universal Reagents for Histology & IHC Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitizing agent.
Biochem/physiol Actions
A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

Specifications

General

Web Name Suffix Override	≥99% purity (HPLC), powder
NACRES	NA.47
PubChem Substance ID	24278439
UNSPSC Code	12171500
EC Number	200-085-6
MDL number	MFCD00006018
Beilstein/REAXYS Number	127172
InChI	1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key	GHASVSINZRGABV-UHFFFAOYSA-N
SMILES string	FC1=CNC(=O)NC1=O
assay	≥99% (HPLC)
form	powder
technique(s)	titration: suitable
color	white
Quality Level	200
Gene Information	human ... TYMS(7298)
mp	282-286 °C (dec.) (lit.)
solubility	1 M NH4OH: soluble
ε<sub>max</sub>	7.07 at 265 nm in 0.1 M HCl
application(s)	diagnostic assay manufacturinghematologyhistology
storage temp.	room temp

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