Merck, F8924-25UG, Fibroblast Growth Factor-10 human

Name: Fibroblast Growth Factor-10 human
Brand: Merck
SKU: F8924-25UG

Size:25 μg, FGF-10, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Catalog Number: F8924-25UG

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Category

Growth Factors & Cytokines

Pack Size25 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Growth Factors & Cytokines

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
FGF10 (fibroblast growth factor 10) is a member of the FGF protein family, which is a mitogen of epithelial origin and has a paracrine activity. It is produced by mesenchymal lineage cells, and acts as a ligand for FGFR, most notably FGFR2b, which is expressed by epithelial cells.
Application
Fibroblast Growth Factor-10 human is suitable for culturing of HUVEC cell line (human umbilical vein endothelial cells) to determine the anti-angiogenic properties of sFLT-1 (soluble fms-related tyrosine kinase-1).
Biochem/physiol Actions
FGF10 (fibroblast growth factor 10) is involved in cell growth, morphogenesis and embryogenesis. It plays an essential role in initiating the formation of limb bud, lung morphogenesis and brain formation during embryogenesis. It acts as a mitogen, where it facilitates the regeneration of epithelia post-bladder urothelial injury. Thus, it might have future applications during bladder transplantation. Studies in Japanese population show that polymosphisms- rs339501, rs12517396, and rs10462070 are linked with severe myopia, and might act as susceptibility factors for the same. In lung cancer cells, FGFR4 reduces the stem cell/self-renewal property of cancer cells, and makes them more susceptible to chemotherapy.
Physical form
Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 50 mM sodium sulfate, 1 mM DTT, 0.5 mM EDTA, pH 7.2, containing 50 μg bovine serum albumin per 1 μg cytokine.
Analysis Note
The biological activity is measured by its ability to stimulate the proliferation of a monkey epithelial cell line 4MBr-5.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.32
MDL number	MFCD01867039
biological source	human
recombinant	expressed in E. coli
assay	>97% (SDS-PAGE)
form	lyophilized powder
potency	28 ng/mL
mol wt	19 kDa by SDS-PAGE
packaging	pkg of 25 μg
storage condition	avoid repeated freeze/thaw cycles
technique(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
UniProt accession no.	O15520
storage temp.	−20°C
Quality Level	100
Gene Information	human ... FGF10(2255)

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Merck, F8924-25UG, Fibroblast Growth Factor-10 human

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