Merck, G1794-2MG, GAP-27

Name: GAP-27
Brand: Merck
SKU: G1794-2MG

Size:2 mg, Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, ≥97% (HPLC)

Catalog Number: G1794-2MG

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Category

Human Primary Cells

Pack Size2 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
GAP-27 has been used as a blocking peptide for Cx43 (connexin 43) gap junctions in FDC (follicular dendritic cells)-B cell cultures.
Biochem/physiol Actions
GAP-27 shares homology with a region of extracellular loops of connexins, and hence, is thought to inhibit junctions formed by the connexins Cx32, Cx40 and Cx43. It highly hinders co-operative cell-cell interactions including the synergized beating of embryonic cardiomyocytes. This peptide reduces osteoclastic activity and survival rates. This peptide significantly reduces acetylcholine-mediated hyperpolarization of smooth muscle cells.
Inhibitor of gap junction signaling in endothelial cells.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.32
MDL number	MFCD11045577
SMILES string	N1([C@@H](CCC1)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](N)CO)CCCNC(=N)N
InChI	1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1
InChI key	SXRAPDIXXYFGJG-MDAHIHQXSA-N
biological source	human
assay	≥97% (HPLC)
form	powder
packaging	pkg of 2 mg
technique(s)	cell culture \| mammalian: suitable
solubility	water: soluble 1.00-1.02 mg/mL, clear, colorless

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Merck, G1794-2MG, GAP-27

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General

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