Merck, GS52-100UG, GST T2-2, Recombinant Human

Name: GST T2-2, Recombinant Human
Brand: Merck
SKU: GS52-100UG

Size:100 μg, glutathione S-transferase theta 2

Catalog Number: GS52-100UG

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Category

Recombinant Enzymes

Pack Size100 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Glutathione S-transferase theta 2 (GSTT2) is an enzyme that in humans is encoded by the GSTT2 gene. GSTT2 is mapped to human chromosome 22q11.2.
as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T2-2 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature.
Biochem/physiol Actions
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The θ class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations.
Preparation Note
The enzyme should be used by the end-user customer within 1 year of receipt.

Specifications

General

NACRES	NA.26
UNSPSC Code	12352200
biological source	human
recombinant	expressed in E. coli
assay	>95% (SDS-PAGE)
form	frozen liquid
specific activity	12.6 units/mg protein
mol wt	25 kDa
concentration	1.91 mg/mL
storage temp.	−70°C
Quality Level	100
Gene Information	human ... GSTT2(2953)

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Merck, GS52-100UG, GST T2-2, Recombinant Human

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