Description
General description
“Cytokine” is a general term used for a diverse group of soluble proteins and peptides which act as regulators under both normal and pathological conditions to modulate the functional activities of individual cells and tissues. These proteins also mediate direct interactions between cells and regulate processes taking place in the extracellular environment. The cytokine group of proteins includes lymphokines, interferons, colony stimulating factors and chemokines. Cytokine and chemokine research plays a significant role in achieving a deeper understanding of the immune system and its multi-faceted response to most antigens, as well as disease states such as inflammatory disease, allergic reactions, irritable bowel disease (IBD), sepsis, and cancer.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 20 analytes in human serum, plasma, and cell culture supernatants.
Analytes included: BAFF/Blys, BRAK/CXCL14, CCL28, CXCL16, HCC-4/CCL16, HMGB1, IFNβ, IL-14, IL-19, IL-24, IL-28B, IL-32α, IL-34, IL-35, IL-36β/IL-1F8, IL-37/IL-1F7, IL-38/IL-1F10, MIP-4, MPIF/CCL23, YKL40
Note: HMGB1 can be measured in serum and plasma samples only.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Features and Benefits
Dynamic Range Optimization: Pre-verified 1:4 serum/plasma dilution minimizes matrix effects while maintaining sensitivity for both high-abundance (e.g., YKL-40) and low-level targets (e.g., IL-34).
Pioneering Research Applications: Decode IL-38’s role in autoimmune regulation and IL-24’s dual pro-inflammatory/oncolytic effects. Investigate HMGB1 as a prognostic marker in critical care or YKL-40 in fibrotic disorders or map chemokine networks (e.g., CXCL16 in atherosclerosis, CCL23 in angiogenesis).
Reduced Hands-On Time: Preconfigured reagents and intuitive protocols simplify high-throughput workflows.
Adaptable Sensitivity: Tailor detection ranges via dilution to capture both abundant (e.g., BAFF) and rare (e.g., IFNβ) analytes.
Legal Information
Luminex is a registered trademark of Luminex Corporation
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
