Merck, I1020-5UG, Interleukin-4 from mouse

Application
Interleukin-4 from mouse has been used:
as a component of cell culture media for class switch recombination assay
to study its therapeutic benefits for mucosal healing
as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)

Biochem/physiol Actions
Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.
Interleukin-4, a lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and bFGF-induced angiogenesis. Human and mouse IL-4 share 50% amino acid sequence identity, but their biological actions are species-specific.
Physical form
Lyophilized, 0.2 μm filtered, with no additives.
Analysis Note
The proliferative activity is tested in culture using mouse HT-2 cells.