Merck, I7378-25G, Indomethacin

Name: Indomethacin
Brand: Merck
SKU: I7378-25G

Size:25 g, 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid, 98.0-102.0%, meets EP testing specifications

Available Catalog Numbers

I7378-100G I7378-10G I7378-25G I7378-5G

Catalog Number: I7378-25G

Pricing

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Category

Phosphatase Inhibitors

Pack Size25 g

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.
Application
Indomethacin has been used:
as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
in the inhibition of prostaglandin E2 (PGE2) in T cells

Biochem/physiol Actions
Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Specifications

General

NACRES	NA.77
PubChem Substance ID	24278173
UNSPSC Code	12161501
EC Number	200-186-5
MDL number	MFCD00057095
Beilstein/REAXYS Number	497341
Web Name Suffix Override	98.0-102.0% (meets EP testing specifications), powder or crystals, COX inhibitor
InChI key	CGIGDMFJXJATDK-UHFFFAOYSA-N
InChI	1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
SMILES string	COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
biological source	synthetic
Gene Information	human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743) mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224) rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)
Quality Level	200
agency	meets EP testing specifications
form	powder or crystals
loss	≤0.5% loss on drying
mp	158-162 °C

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Merck, I7378-25G, Indomethacin

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