Merck, M3445-10MG, Magnolol

General description
Magnolol is a bioactive neolignan extracted from the root and stem bark of different Chinese herbal Magnolia trees. It has a hydroxylated bi-phenoid structure like that of its structural isomer honokiol. It is a lipophilic compound.
Application
Magnolol has been used:
to test its effect on muscle atrophy and macrophage subtypes in sarcopenia mouse model
to test its inhibitory effect on human umbilical vein endothelial cells (HUVECs) in angiogenesis assay
to test its anti-fungal effects on growth, ultrastructure, and biofilm formation of Candida spp. strains
in the preparation of immobilized amino-functionalized mesoporous silica particles for prolonged-release studies

Biochem/physiol Actions
Magnolol exerts anti-depressant and, neurodegenerative properties. It is also considered to be a potent anti-cancer agent for its involvement in reducing cell proliferation, cell cytotoxicity, and inducing apoptosis.
Magnolol is a bioactive plant component isolated from the root and stem bark of Magnolia officinalis with antifungal, antibacterial and antioxidant effects. Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. It also appears to have anti-inflammatory properties related to vascular disorders such as atherosclerosis due to its ability to inhibit IL-6-induced STAT3 activation.