Merck, M3536-250MG, Mycophenolic acid

Name: Mycophenolic acid
Brand: Merck
SKU: M3536-250MG

Size:250 mg, 6-(1, 3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, NSC 129185, powder, BioReagent, suitable for cell culture

Available Catalog Numbers

M3536-250MG M3536-50MG

Catalog Number: M3536-250MG

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Category

Antibiotics & Antimycotics

Pack Size250 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.
Biochem/physiol Actions
Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.
Preparation Note
Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.
Disclaimer
As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

Specifications

General

Web Name Suffix Override	powder, suitable for cell culture, BioReagent
NACRES	NA.76
PubChem Substance ID	24896854
UNSPSC Code	12352207
EC Number	246-119-3
MDL number	MFCD00036814
Beilstein/REAXYS Number	1295848
InChI key	HPNSFSBZBAHARI-RUDMXATFSA-N
InChI	1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
SMILES string	COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
biological source	Penicillium brevicompactum
product line	BioReagent
form	powder
technique(s)	cell culture \| mammalian: suitable
color	white to yellow-white
mp	<143.0 °C
solubility	methanol: 50 mg/mL
web metadata keyword.default	xanthine-guanine phosphosribosyl transferase, gene expression selection agent
mode of action	enzyme \| inhibits
storage temp.	2-8°C
Quality Level	300
Gene Information	human ... IMPDH1(3614), IMPDH2(3615)

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