Merck, MAB2638, Anti-Integrin beta7 Antibody, clone TN114

General description
Integrin beta7 is an adhesion molecule belonging to the integrin beta chain family. It forms heterodimers with the alpha subunit, most notably the integrin alpha4 and alphaE subunits, functioning to mediate migration and homing of lymphocytes to the gut-associated lymphoid tissue (GALT). The heterodimer formed with alpha4, α4β7, is specifically involved in the homing and migration of lymphocytes to the gut, while αEβ7 is involved in the binding of T lymphocytes to epithelial cells and is induced by TGFβ1. Integrin beta7 has been observed in several different leukocyte lines.
~ 86 kDa
Immunogen
Epitope: Unknown
Purified human integrin beta7 protein.
Application
Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.
Research Category
Cell Structure
Research Sub Category
Integrins
Biochem/physiol Actions
The antibody recognizes Integrin beta7.
Physical form
Format: Purified
Protein G Purified
Purified armenian hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human peripheral blood mononuclear cells (PBMC′s).
Evaluated by Flow Cytometry in human PBMC′s.

Flow Cytometry Analysis: 1 µg/mL of this antibody detected Integrin beta7 on human PBMC′s.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.