Merck, MAK635-1KT, Parallel Artificial Membrane Permeability Assay BBB Kit

General description
Membrane permeability is an important characteristic for evaluating compounds as potential drug candidates. Drugs often need to cross cell membranes in order to reach their target of action and this makes a compound’s ability to passively cross these membranes an important characteristic to evaluate. The Blood Brain Barrier (BBB) is made of brain endothelial cells with tight junctions. Rapid and early screening of compounds for BBB penetration is highly desirable for drug discovery. Permeability can be evaluated by cell-based methods; however, these methods are often expensive and time consuming. Parallel Artificial Permeability Assays (PAMPA) offer researchers a quick, inexpensive method of evaluating the permeability of test compounds. The PAMPA BBB Kit is designed to aid in evaluating BBB permeability.

The PAMPA BBB Kit provides all the necessary components to run a Parallel Artificial Permeability Assay for Blood Brain Barrier studies.
Application
Suitable for the quantitative determination of blood brain barrier (BBB) membrane permeability of test compounds.