Merck, MC0SP07FS1, Millistak+® HC Pro Pod Depth Filter

General description The Millistak+® HC Pro Pod Depth Filter (high capacity synthetic media) is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter offerings. This unit, featured in a Process Scale Pod format with a C0SP media grade, supports primary and secondary clarification as well as downstream filtration applications. Application Primary clarification directly out of the bioreactor Features and Benefits Filter Grade: C0SP Synthetic materials of construction Reduce TOC extractables and pre-use flush volume requirements by 50% No beta glucans to interfere with limulous amoebocyte lysate (LAL) testing for bacterial endotoxins Lot to lot consistency for successful development and implementation of robust clarification processes Depth filter media formulation & design Provide as much as two times the filtration capacity with equivalent filter retention properties over commercial DE-based benchmarks Improved HCP impurity clearance Disposable Pod device Flexible, modular format offers scalability from 5 to 12,000 liters or more Robust device format; easy to use and set up Trace metals were measured post pure water flush of 50 L/m2 of surface area and 24-hour static soak in pure water. Values based on average of metals extractibles data from three separate uPod device lots. The analysis was made by ICP-MS. The devices were not autoclaved. Preparation Note Sterilization Method Integrity is maintained after 1 autoclave cycle of 60 min @ 123 ºC. Filtration performance may be impacted post autoclave. Recommended for post use decontamination only. Analysis Note Product Water Conductivity at 25°C: after a pure water flush 50 L/m2 (5 liter per ft2) of media surface area (300 LMH, 10 min). At the end of the flush, a sample was pulled for conductivity measurement. Devices were not autoclaved. Legal Information Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany MILLISTAK+ is a registered trademark of Merck KGaA, Darmstadt, Germany