Merck, MSPV10FS1, Viresolve® Pod Prefilter

The Merck Millipore Viresolve prefilter Pod provides 1.1 m² of hydrophilic adsorptive prefiltration area for conditioning protein-process streams before a downstream Viresolve Pro virus-removal filter. Its media use cellulose fibers with inorganic filter aid and mixed cellulose ester components, enclosed in a pod housing with disposable 1.5-inch Tri-Clamp inlet and outlet connections. The listed nominal process-volume range is 200–400 L, although actual capacity depends on feed composition and fouling characteristics. Maximum differential pressure is 2.1 bar in either flow direction. The prefilter reduces particulate and fouling challenges to a subsequent virus-retentive membrane; it is not itself a validated virus-removal filter. Install the pod in the appropriate Millistak+ holder, establish the required wetting and flushing protocol, and qualify filtration performance using representative process material. Monitor differential pressure and flow throughout operation, and document process-specific suitability and any sterilization or integrity-test requirements before use in a regulated manufacturing process.