Merck, MX1390, 1-Methyl-2-pyrrolidone

General description
NMP, also known as N-Methyl-2-pyrrolidone, is a versatile, water-miscible solvent widely recognized for its ability to improve the solubility and permeability of a broad range of pharmaceutical compounds. Its high thermal stability with a boiling point of 202 °C is well-suited for formulations that require heat sterilization. These properties make it a reliable and effective solubilizing agent for pharmaceutical development.
Application
NMP may be used as a solvent in a modified Fmoc-deprotection during solid-phase peptide synthesis for the reduction of diketopiperazine formation.
in gel permeation chromatography (GPC) or size-exclusion chromatography (SEC) for analyzing high-molecular-weight polymers

OmniSolv®
Packaging
M-Bottle for Solvents
As a global leader in lab reagents, we are constantly looking for new ways to optimize the safety of our products. The newly developed 4L solvent bottle design features advanced sealing technology that eliminates leaks to make the handling of solvents safer and more convenient than ever before.
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is packaged in 4L amber glass bottle
Preparation Note
Product filtered through a 0.2 μm filter
Analysis Note
Assay (GC)99.7% min
Color (APHA)10 max
Filtered through 0.2 µm filterTo pass test
FormClear liquid
Infrared SpectrumConforms to standard
Residue after ignition5ppm max
Titrable base1µeq/g max
UV Abs. at 270 nm1.00AU max
UV Abs. at 300 nm0.20AU max
UV Abs. at 325 nm0.10AU max
UV Abs. at 350 nm0.03AU max
UV Abs. at 400 nm0.005AU max
UV Cut-off270nm max
Water (H2O)0.08% max

Legal Information
OMNISOLV is a registered trademark of Merck KGaA, Darmstadt, Germany