Merck, P8615-10UG, Phosphoinositide 3-kinase p110γ human

General description
Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.
Biochem/physiol Actions
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.
Physical form
Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.
Other Notes
1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.