Merck, PHR1009-1G, Caffeine

Name: Caffeine
Brand: Merck
SKU: PHR1009-1G

Size:1 g, 1, 3, 7-Trimethylxanthine, Pharmaceutical Secondary Standard; Certified Reference Material

Catalog Number: PHR1009-1G

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Category

Pharmaceutical Reference Standards

Pack Size1 g

TagsAnalytical Chemistry Reference Materials Certified Reference Materials

CollectionsMerck Certified Reference Materials: CRMs for Calibration, QC & Instrument Validation Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.
Application
Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Specifications

General

UNSPSC Code	12352210
NACRES	NA.24
PubChem Substance ID	329823040
MDL number	MFCD00005758
Beilstein/REAXYS Number	17705
InChI	1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
SMILES string	CN1C(=O)N(C)c2ncn(C)c2C1=O
InChI key	RYYVLZVUVIJVGH-UHFFFAOYSA-N
grade	certified reference material
agency	traceable to Ph. Eur. C0100000
API family	dimenhydrinate, caffeine, pentoxifylline
CofA	current certificate can be downloaded
Gene Information	human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
Quality Level	300
technique(s)	HPLC: suitable
mp	234-236.5 °C (lit.)
application(s)	pharmaceutical (small molecule)
format	neat
storage temp.	2-30°C

FAQs

Question: What grade is supplied?

Answer:The material is a pharmaceutical secondary standard and certified reference material.

Question: What quantity is included?

Answer:This configuration contains 1 g.

Question: Which analytical techniques are supported?

Answer:The standard is suitable for HPLC and gas-chromatography methods.

Application Note

Caffeine is supplied as a pharmaceutical secondary standard and certified reference material for analytical quality control. This configuration contains 1 g of neat reference material. Caffeine has a molecular weight of 194.19 g/mol and CAS number 58-08-2. The material is traceable to corresponding pharmacopoeial primary standards and is suitable for HPLC and gas-chromatography methods. It can support assay calibration, identity testing, method development, release testing, and quantitative analysis of caffeine in pharmaceutical, food, beverage, and related quality-control samples. The ready-to-use secondary-standard format reduces the need to prepare an internal working standard from a primary reference material. Certified lot values and traceability information are supplied with the certificate of analysis.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

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