Merck, R2146-1MG, Radicicol from Diheterospora chlamydosporia

Name: Radicicol from Diheterospora chlamydosporia
Brand: Merck
SKU: R2146-1MG

Size:1 mg, Monorden, [1aS-(1aR*, 2Z, 4E, 14*, 15aR*)]-8-Chloro-1a, 14, 15, 15a-tetrahydro-9, 11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6, 12(7H)-dione, solid

Available Catalog Numbers

R2146-1MG R2146-5MG

Catalog Number: R2146-1MG

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Category

Phosphatase Inhibitors

Pack Size1 mg

TagsGreener Alternative Products

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Radicicol from Diheterospora chlamydosporia has been used as an inhibitor of heat shock protein 90 (Hsp90):
to study its effects on lifespan extension and health in Caenorhabditis elegans
to study its effects on protein aggregation in yeast
to study its effects on xanthone sensitized cancer cells

Biochem/physiol Actions
Radicicol is an antifungal macrolactone antibiotic that is found in Diheterospora chlamydosporia, Chaetomium chiversii, and Monosporium bonorden. It functions as an inhibitor of tyrosine kinase and heat shock protein 90 (Hsp90). Radicicol is involved in the suppression of transformation of various proto-oncogenes such as Ras, Mos, and Src. It also suppresses the activity of mitogen-induced cyclooxygenase-2 (COX-2) and phosphoinositide-dependent kinase 1 (PDK1). Radicicol is involved in arresting the cell cycle at the G1-S phase. It exhibits ant-cancer and anti-angiogenic activity in vivo.
Disclaimer
Photosensitive

Specifications

General

UNSPSC Code	51111800
PubChem Substance ID	24899351
NACRES	NA.77
Web Name Override	Radicicol
Web Name Suffix Override	from Diheterospora chlamydosporia, Tyrosine kinase inhibitor, solid
MDL number	MFCD06795865
SMILES string	C[C@@H]1C[C@H]2O[C@@H]2C=C\C=C\C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1
InChI	1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
InChI key	WYZWZEOGROVVHK-GTMNPGAYSA-N
form	solid
greener alternative product score	old score: 15new score: 9Find out more about DOZN™ Scoring
greener alternative product characteristics	Waste PreventionAtom EconomyUse of Renewable FeedstocksLearn more about the Principles of Green Chemistry.
sustainability	Greener Alternative Product
color	white to yellow-white
solubility	ethanol: 10 mg/mL
antibiotic activity spectrum	fungi
greener alternative category	, Re-engineered
mode of action	enzyme \| inhibits

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