Merck, S2626-1G, Spermidine

Name: Spermidine
Brand: Merck
SKU: S2626-1G

Size:1 g, 1, 8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1, 4-diaminobutane, ≥99% (GC)

Available Catalog Numbers

S2626-1G S2626-25G S2626-5G

Catalog Number: S2626-1G

Pricing

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Category

Phosphatase Inhibitors

Pack Size1 g

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.
Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.
Application
Spermidine has been used:
in the preparation of 5x transcription buffer
in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
as a standard in the analytical study of rat brain polyamines (185)

Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.
Other Notes
Store under inert gas. Air sensitive; strongly hygroscopic.
Disclaimer
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Specifications

General

Web Name Suffix Override	synthetic, ≥99% (GC), neuronal nitric oxide synthase (nNOS) inhibitor, solid or liquid (clear)
NACRES	NA.32
PubChem Substance ID	24899529
UNSPSC Code	12352200
EC Number	204-689-0
MDL number	MFCD00008229
Beilstein/REAXYS Number	1698591
InChI key	ATHGHQPFGPMSJY-UHFFFAOYSA-N
InChI	1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
SMILES string	NCCCCNCCCN
biological source	synthetic
assay	≥99% (GC)
form	solid or liquid (clear)
impurities	DNase, none detected
refractive index	n20/D 1.479 (lit.)
mp	22-25 °C
solubility	water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
density	0.925 g/mL at 25 °C (lit.)
storage temp.	room temp
Gene Information	rat ... Ppm1a(24666)
Quality Level	200

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