Merck, SAB3700372-2MG, Anti-Guinea Pig IgG (H+L)-Peroxidase antibody produced in goat

General description
Antibody format: IgG
The IgG (immunoglobulin G) structure possesses four polypeptide chains containing two identical γ heavy (H) chains and two identical κ or λ light (L) chains of 50kDa and 25kDa respectively. The chains are interlinked with a disulfide bond. Both the L and the H chains consist of a variable domain at the N-terminal. The C-terminal bears′ constant domains: three in H chain with a hinge region and one in the L chain. IgG contributes to 10−20% of plasma protein and is regarded as one of the most abundant serum protein. IgG antibody is enriched in mother′s milk.
Immunogen
Guinea Pig IgG whole molecule
Biochem/physiol Actions
IgG (immunoglobulin G) antibody protects against bacterial, fungal and viral infections. It helps in opsonization, complement fixation and antibody-dependent cell-mediated cytotoxicity. IgG antibody has its function similar to IgM antibody in complement system activation. IgG participates in hypersensitivity type II and type III. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
This product was prepared from monospecific antiserum by immunoaffinity chromatography using Guinea Pig IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against Anti-Peroxidase, Anti-Goat Serum, Guinea Pig IgG and Guinea Pig Serum.
Physical form
Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 10 mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free
Preparation Note
Reconstitute with 1.0 mL deionized water (or equivalent).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.