Merck, SAB5702071-100UL, Anti-Bmi1 Antibody, clone 6H9B0, Rabbit Monoclonal

General description
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 227-326 of human Bmi1 (P35226).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB