Merck, SAB5702136-100UL, Anti-Cullin 1 Antibody, clone 5I5Z3, Rabbit Monoclonal

General description
The cullin family proteins are scaffold proteins for the Ring finger type E3 ligases. Humans express seven cullin proeins: CUL1–3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. The Cullin-RING-finger type E3 ligases are important regulators in early embryonic development, as highlighted by genetic studies demonstrating that knock-out of CUL1, CUL3, or CUL4A in mice results in early embryonic lethality.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 677-776 of human Cullin 1 (Q13616).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB