Merck, SAB5702138-100UL, Anti-ANPRB/NRP2 Antibody, clone 1S1H1, Rabbit Monoclonal

General description
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ANPRB/NRP2 (P20594).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB