Description
General description
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR2/CKR2 (P41597).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB