Merck, SAB5702413-100UL, Anti-Caldesmon Antibody, clone 6M5Q9, Rabbit Monoclonal

General description
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 694-793 of human Caldesmon (Q05682).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB