Merck, SAB5702505-100UL, Anti-ALAS1 Antibody, clone 2K1G3, Rabbit Monoclonal

General description
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 541-640 of human ALAS1 (P13196).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB