Merck, SBR00011-2ML, Clarithromycin

Name: Clarithromycin
Brand: Merck
SKU: SBR00011-2ML

Size:2 mL, 6-O-methyl erythromycin, Ready Made Solution, 50 mg/mL in DMSO

Catalog Number: SBR00011-2ML

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Category

Antibiotics & Antimycotics

Pack Size2 mL

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Application
Clarithromycin may be used for-
the study of the effects of clarithromycin on rate-dependent changes in QT, Tp₋eand proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
the study of the synergism of NAB741 with clarithromycin in microtiter plates.

Biochem/physiol Actions
Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.
Packaging
2ML
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Specifications

General

UNSPSC Code	51102829
PubChem Substance ID	329824644
NACRES	NA.85
MDL number	MFCD00865140
SMILES string	N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C
InChI	1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI key	AGOYDEPGAOXOCK-KCBOHYOISA-N
form	liquid
storage condition	dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
concentration	50 mg/mL in DMSO
color	colorless to faint yellow
antibiotic activity spectrum	Gram-positive bacteria
mode of action	protein synthesis \| interferes
storage temp.	−20°C
Quality Level	200

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Merck, SBR00011-2ML, Clarithromycin

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