Merck, SCT094, BioTracker NIR FolateReceptor Live Cell Dye

General description
Folate receptors (FRs) are membrane bound surface proteins involved in folic acid uptake. FRs are frequently overexpressed in a large number of solid tumors including cancers of the ovary, breast and lung. FRs are attractive candidates for cancer imaging and targeted therapies.BioTracker NIR Folate Receptor Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection of folate receptors in vivo. This probe exhibits very low background fluorescence and high tumor-to-background ratio in FR-expressing tumor-bearing mice within 30 min (1).Reference:1. Numasawa, Koji, et al. "A Fluorescent Probe for Rapid, High‐Contrast Visualization of Folate‐Receptor‐Expressing Tumors In Vivo." Angewandte Chemie International Edition 59.15 (2020): 6015-6020.
Application
Purity ≥ 95% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Features and Benefits
Near-Infrared probe for detection and visualization of folate receptors in vivo.
Physical form
Lyophilized. Green solid.
Preparation Note
Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.