Merck, SMB00287-10MG, Formycin A

Name: Formycin A
Brand: Merck
SKU: SMB00287-10MG

Size:10 mg, 1-C-(7-Amino-1H-pyrazolo[4, 3-d]pyrimidin-3-yl)-1, 4-anhydro-(1S)-D-Ribitol, 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4, 3-d]pyrimidine, 8-Aza-9-deazaadenosine, Formycin, NSC 102811, from Streptomyces kaniharaensis, ≥98% (HPLC)

Catalog Number: SMB00287-10MG

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Category

Antibiotics & Antimycotics

Pack Size10 mg

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: nucleoside
Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.
Biochem/physiol Actions
Formycin A possess antitumor function, along with its antibacterial and antiviral activity.
Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP).
Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.
Packaging
10MG
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

Specifications

General

UNSPSC Code	51102829
NACRES	NA.85
PubChem Substance ID	329824924
MDL number	MFCD00036807
Beilstein/REAXYS Number	624229
InChI key	OIRDTQYFTABQOQ-KQYNXXCUSA-N
SMILES string	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
InChI	1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
biological source	Streptomyces kaniharaensis
assay	≥98% (HPLC)
form	powder
storage condition	(Keep container tightly closed in a dry and well-ventilated place.)
color	white to off-white
solubility	DMSO: soluble 1 mg/mL
antibiotic activity spectrum	viruses (Antiretroviral)
mode of action	enzyme \| inhibits
storage temp.	−20°C
Quality Level	200
Gene Information	human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

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Merck, SMB00287-10MG, Formycin A

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