Merck, SML0287-5MG, 680C91

Name: 680C91
Brand: Merck
SKU: SML0287-5MG

Size:5 mg, 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl)-1H-indole, ≥98% (HPLC)

Available Catalog Numbers

SML0287-25MG SML0287-5MG

Catalog Number: SML0287-5MG

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Category

Phosphatase Inhibitors

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
680C91 has been used:
as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryos
as a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assay
as a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells

Biochem/physiol Actions
680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. Kynurenin has recently been identified as an endogenous lignd of the arylhydrocarbon receptor (AHR). TDO is highly expressed in glioma cells, and contributes to AHR-mediated glioma cell survival and suppression of anti-tumor immune responses.
680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO).
680C91 shows no inhibitory effects against monoamine oxidase A and B, indoleamine 2,3-dioxygenase and serotonin (5-HT) uptake, and 5-HT1A,1D,2A, and 2C receptors.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	329825295
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), Tryptophan 2,3-dioxygenase inhibitor, powder
MDL number	MFCD20926361
SMILES string	Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1
InChI	1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
InChI key	YBSDQTBCNYWBMX-ONEGZZNKSA-N
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: ≥10 mg/mL
storage temp.	2-8°C
Quality Level	100

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