Merck, T-038-1ML, (+)-11-Nor-Δ9-THC-9-carboxylic acid glucuronide solution

General description
11-Nor-Δ⁹-THC-9-carboxylic acid glucuronide is the phase II metabolite of the phytocannabinoid ∆⁹-tetrahydrocannabinol (THC). This certified Snap-N-Spike® reference solution is suitable for numerous GC/MS or LC/MS applications from pharmaceutical testing and research to clinical toxicology or forensic analysis. This Certified Reference Material provides added value in allowing calibration of THC acid glucuronide by LC-MS/MS methods without the need for an added hydrolysis step.
Application
The Certified Spiking Solution® is suitable for (+)-11-Nor-Δ⁹-THC-9-carboxylic acid glucuronide testing by HPLC, GC/MS, or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. The Certified Reference Material (CRM) in solution can also be used as follows:Development of an automated sample preparation method based on solid phase extraction (SPE) to determine ∆⁹-tetrahydrocannabinol (THC) and its three primary metabolites in a variety of matrices, such as serum, saliva, and urine using liquid chromatography-mass spectrometry (LC-MS)
Liquid chromatographic-tandem mass spectrometric (LC-MS/MS) determination of cannabinoids and their metabolites in whole blood samples
Detection and quantification of 11-Nor-∆⁹-tetrahydrocannabinol-9-carboxylic acid glucuronide (THC-COOH-glu) in hair samples by ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
Simultaneous residue analysis of phytocannabinoids, their metabolites, and amphetamine-type stimulants (ATS) in 11 hair samples obtained from drug users by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
Determination of measurement uncertainty in the quantitative analysis of 11-nor-∆⁹-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) and its glucuronide analogue (THC-COOH-glu) from urine samples by using LC-MS/MS

Features and Benefits
Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
Rigorously tested through real-time stability studies to ensure accuracy and shelf life
Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
Flame sealed under argon into ampoules for long-term shelf life
Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Other Notes
Not to be used for immunoassay
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany