Merck, T1408-1G, holo-Transferrin bovine

General description
Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.
Application
Holo-Transferrin bovine has been used:
as a RPMI-1640 medium supplement for culturing cancer cell lines
as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
as a standard for strong anion exchange (SAX) reactor measurements

Biochem/physiol Actions
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
Analysis Note
Purity by agarose gel electrophoresis.