Merck, V3639-5ML, Valinomycin

Name: Valinomycin
Brand: Merck
SKU: V3639-5ML

Size:5 mL, Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid, Ready Made Solution, ~1 mg/mL in DMSO

Catalog Number: V3639-5ML

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Category

Antibiotics & Antimycotics

Pack Size5 mL

TagsChemistry & Biochemicals Biochemicals Antibiotics

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: peptide
Application
Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.
Biochem/physiol Actions
K⁺-selective ionophore which uncouples oxidative phosphorylation.
K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.
Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Specifications

General

UNSPSC Code	51102829
NACRES	NA.76
PubChem Substance ID	24900743
MDL number	MFCD00005114
Beilstein/REAXYS Number	78657
SMILES string	CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
InChI key	FCFNRCROJUBPLU-RPUZOQEISA-N
InChI	1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
biological source	Streptomyces sp.
assay	≥90% (HPLC)
form	liquid
storage condition	(Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
concentration	~1 mg/mL in DMSO
color	colorless
antibiotic activity spectrum	Gram-positive bacteria

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Merck, V3639-5ML, Valinomycin

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