Promega, CS1679C169, NanoBRET® BiBRET PPI Starter System

Study Selective Signaling and Compound Activity in a Live-Cell Format
The NanoBRET® BiBRET PPI Starter System enables real-time, live-cell analysis of protein interactions using a single bidirectional vector. This system is ideal for evaluating mutant-selective responses and compound effects with high sensitivity and reproducibility. Utilize the power of BiBRET to study selective signaling and compound activity in a biologically relevant, live-cell format.
Quickly detect subtle changes in protein:protein interactions across variants
Minimize variability with co-expression from a single plasmid
Monitor compound activity and signaling specificity in a physiologically relevant format
Compatible with high-throughput screening and kinetic studies
Using the NanoBRET® BiBRET PPI Starter System, RAS-RAF interactions were monitored in real time across multiple KRAS variants following treatment with BI-2852, a known RAS pathway inhibitor.