Promega, CS354807, Incretin-Related Bioassays

Measure Functional Activity of Incretin-Related Metabolic Regulators (GLP-1, GIP and Glucagon)
Metabolic regulators such as GLP-1, GIP and glucagon are hormones that play key roles in maintaining energy and glucose balance in the body. GLP-1 and GIP, known as incretins, enhance insulin secretion in response to food intake, helping to lower blood glucose levels. In contrast, glucagon raises blood glucose by promoting the release of glucose from the liver. Together, these hormones coordinate to regulate appetite, insulin and glucagon secretion, and nutrient metabolism, making them central to metabolic health. Understanding and measuring the activity of these key metabolic regulators is essential for advancing metabolic disease research and drug development.
Researchers need to determine potency of their molecule with a biologically relevant model; the GLP-1, GIP and Glucagon Bioassays provide mechanism-of-action-based platforms for the detection and quantitation of agonist activity in research, drug development and QC settings. These assays enable precise functional readouts of receptor activation, offering biologically relevant data that cannot be captured by physicochemical methods alone.