Promega, J2272, GITR Bioassay

Name: GITR Bioassay
Brand: Promega
SKU: J2272

Measure Potency and Stability of Biologics Designed to Activate GITR, Prequalified according to ICH guidelines, 96- and 384-well plate formats, Supplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format, Configuration: Cell Propagation Model/2 × 1.0ml

Catalog Number: J2272

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Category

Sample Acquisition Plates

TagsBioassays Immune Checkpoint Bioassays

Description

Simple Bioassay, Consistent Results
The GITR Bioassays are bioluminescent cell-based assays used to measure the potency and stability of ligands or agonist antibodies that bind and activate GITR. GITR (CD357/TNFRSF18), a member of the tumor necrosis factor (TNF) receptor superfamily, is a costimulatory receptor widely expressed on most immune cells and further upregulated on activated T cells. When engaged with GITR ligand (GITRL) on the cell surface, GITR enhances subsequent T cell expansion and cytokine production including interleukin-2 (IL-2) and IL-9.
The GITR Bioassay reflects the mechanism of action (MOA) of biologics designed to activate GITR.
Control Ab, Anti-GITR, is a rabbit anti-human GITR agonist antibody. It can be used as a positive control in the GITR Bioassays (Cat.# JA2291, JA2295, J2272) in the presence of FcγRIIb CHO-K1 Cells (Cat.# J2232, JA2251, JA2255).

Specifications

{"type": "table", "rows": [{"name": "GITR Effector Cells (CPM)", "conditions": {"Part #": "J227A", "Size": "2 × 1ml"}}]}

Ordering

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