Promega, JA2295, GITR Bioassay

Name: GITR Bioassay
Brand: Promega
SKU: JA2295

Measure Potency and Stability of Biologics Designed to Activate GITR, Prequalified according to ICH guidelines, 96- and 384-well plate formats, Supplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format, Configuration: Thaw-and-Use Kits/5X each component

Catalog Number: JA2295

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Category

Sample Acquisition Plates

Pack Size1 vial

TagsBioassays Immune Checkpoint Bioassays

Description

Simple Bioassay, Consistent Results
The GITR Bioassays are bioluminescent cell-based assays used to measure the potency and stability of ligands or agonist antibodies that bind and activate GITR. GITR (CD357/TNFRSF18), a member of the tumor necrosis factor (TNF) receptor superfamily, is a costimulatory receptor widely expressed on most immune cells and further upregulated on activated T cells. When engaged with GITR ligand (GITRL) on the cell surface, GITR enhances subsequent T cell expansion and cytokine production including interleukin-2 (IL-2) and IL-9.
The GITR Bioassay reflects the mechanism of action (MOA) of biologics designed to activate GITR.
Control Ab, Anti-GITR, is a rabbit anti-human GITR agonist antibody. It can be used as a positive control in the GITR Bioassays (Cat.# JA2291, JA2295, J2272) in the presence of FcγRIIb CHO-K1 Cells (Cat.# J2232, JA2251, JA2255).

Specifications

{"type": "table", "rows": [{"name": "GITR Effector Cells", "conditions": {"Part #": "J229A", "Size": "5 × 0.5ml"}}, {"name": "Fetal Bovine Serum", "conditions": {"Part #": "J121A", "Size": "5 × 4ml"}}, {"name": "RPMI 1640 Medium", "conditions": {"Part #": "G708A", "Size": "5 × 36ml"}}, {"name": "Bio-Glo™ Luciferase Assay Buffer", "conditions": {"Part #": "G719A", "Size": "5 × 10ml"}}, {"name": "Bio-Glo™ Luciferase Assay Substrate", "conditions": {"Part #": "G720A", "Size": "5 × 1 vial"}}]}

Ordering

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