Proteintech, 22305-1-AP-20ul, Amylin Polyclonal antibody

22305-1-AP targets Amylin in IHC, ELISA applications and shows reactivity with human, rat, mouse samples.
Tested Applications
Positive IHC detected in: human pancreas tissue, mouse pancreas tissue, rat pancreas tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0
Recommended dilution
Immunohistochemistry (IHC): IHC : 1:20-1:200
Background Information
IAPP, also known as Amylin, is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring a tumor of the pancreas that is derived from beta cells and secretes INS. IAPP is co-secreted with INS by pancreatic β-cells and largely contributes to glycemic control. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.