Description
CIMmultus®is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus®columns can be used as single-use disposable or multi-use columns. They are available in a variety of volume ranges – from 1mL for screening and method development purposes to 8000mL for industrial manufacturing.
CIMmultus®C4 HLD employs a high density of butyl ligands to achieve strong surface hydrophobicity. Relying on hydrophobic interaction chromatography (HIC), this column is a must for nucleic acid separations, providing an excellent solution for the purification of pDNA and RNA.
C4 (butyl) high ligand density (HLD) features:
C4 (butyl) high ligand density (HLD) features:
Strongly hydrophobic, uncharged
Working range, pH 2–10
Highly effective for removing proteins from nucleic acids (pDNA, RNA)
Your benefits:
Very fast processes by convective mass transport
Resolution independent of flow
Ready to use columns
High-capacity for large molecules due to fully accessible void volume in the channels
Laminar flow minimizes shear stress resulting in high yields
