Thermo Fisher, 74204-254630, Accucore™ XL C8 HPLC Columns

Accucore™ XL C8 HPLC Column, 250 x 4.6 mm, 4 µm is used to improve conventional reversed-phase HPLC separations while staying within standard HPLC operating pressures. It uses a high-coverage C8 bonded phase on 4 µm solid-core ultrapure silica particles, combining moderate hydrophobic retention with the reduced band broadening associated with the Accucore core-enhanced particle design. The analytical column measures 4.6 mm ID × 250 mm and has an 80 Å pore size, 90 m²/g surface area, 4% carbon load, and endcapped C8 chemistry. It supports pH 2–9, temperatures up to 60 °C, and pressures up to 8700 psi (600 bar). The phase is suited to moderately hydrophobic analytes and to methods where a less hydrophobic phase provides more appropriate retention than C18. Automated packing and robust bonding technology support reproducibility and long column life, while the 250 mm analytical format provides the specified geometry for laboratories transferring or optimizing conventional HPLC methods.