Tosoh, 0022884, TOYOPEARL GigaCap Q-650S

TOYOPEARL GigaCap Q-650S is a high capacity, high resolution anion exchange resin optimized for the capture and purification of both small and large proteins, including oligonucleotides and monoclonal antibodies. The resin is composed of a base material of hydroxylated methacrylic polymer beads that have been chemically modified to provide a higher number of anionic binding sites and functionalized with quaternary amine (Q) strong anion exchange groups. This resin has a 100 nm pore size and a 35 µm bead size. TOYOPEARL GigaCap Q-650S has dynamic binding capacities approaching 190 g/L for bovine serum albumin , maintains high capacity at increased linear velocities, has good pressure-flow characteristics, and will withstand back pressures up to 0.3 MPa . The high capacity, combined with the 35 µm mean particle size, makes TOYOPEARL GigaCap Q-650S ideal for high resolution applications. TOYOPEARL GigaCap Q-650 media has excellent binding and elution kinetics, which results in a more concentrated protein fraction collected during the elution step.