Tosoh, 0045045, Ca⁺⁺Pure-HA

CaPure-HA is a hydroxyapatite resin used in the chromatographic separation of biomolecules. Unlike other resins available from Tosoh Bioscience, CaPure-HA is both the ligand and the base bead. CaPure-HA is specifically developed for the purification of monoclonal and polyclonal antibodies, the separation of antibody isoforms, isozymes, the purification of antibody fragments, and the isolation of single-stranded from double-stranded DNA. CaPure-HA resin has been sintered at high temperatures for increased mechanical and chemical stability, allowing it to withstand the rigors of industrial-scale applications. CaPure-HA has a demonstrated dynamic binding capacity (DBC), at 10% breakthrough, of greater than 20 g/L for lysozyme at residence times as low as one minute and greater than 30 g/L for human IgG at residence times as low as 2 minutes. CaPure-HA provides exceptional separation properties and unequalled selectivity and resolution for multiple classes of biomolecules. The highly selective and robust nature of CaPure-HA offers the flexibility to use this resin at any stage in a process from capture to final polishing.