Description
Key facts
CAS number:256414-75-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:440.4 Da,
Molecular formula:C20H10F6N2OS,
PubChem:4077460,
Nature:Synthetic,
Solubility:Soluble in DMSO to 20 mMSoluble in ethanol to 20 mM,
Biochemical name:5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole,
Biological description:Potent, selective sphingosine-1-phosphate (S1P1) agonist (EC50 = 13 nM). Does not activate S1P2, S1P3, S1P4 or S1P5 receptors. Cell-permeable and active *in vivo*.,
Canonical smiles:C1=CC=C(C=C1)C2=C(SC(=C2)C3=NC(=NO3)C4=CC(=CC=C4)C(F)(F)F)C(F)(F)F,
InChi:InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H,
InChiKey:OYMNPJXKQVTQTR-UHFFFAOYSA-N,
IUPAC Name:5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S1P1 also known as EDG1 and to some extent EDG8 represents a receptor for sphingosine-1-phosphate (S1P). This receptor belongs to the G-protein-coupled receptor (GPCR) family and plays a significant role in cellular communication. It has a molecular mass of approximately 43 kDa. Scientists observe S1P1 expression in a wide range of tissues with notable presence in endothelial cells immune cells and neural tissues. Its mechanistic function involves binding the lipid signaling molecule sphingosine-1-phosphate activating intracellular signaling cascades.
Biological function summary
S1P1 regulates critical processes such as vascular homeostasis immune cell trafficking and endothelial barrier integrity. Importantly it forms part of a multi-subunit complex that includes other proteins like G-proteins. Upon activation by S1P the receptor can lead to cytoskeletal rearrangements and changes in cell morphology. S1P1’s function is linked closely with immune system modulation influencing lymphocyte circulation and migration.
Pathways
S1P1 participates actively in the sphingolipid signaling pathway and the PI3K/AKT pathway. This receptor interacts with molecules like Rac and RhoA which are essential for maintaining endothelial barrier function. Through these pathways S1P1 influences processes such as cell migration and proliferation making it important for maintaining vascular system dynamics. Its relationship with PI3K leads to the activation of downstream effectors necessary for cell survival and growth.
S1P1 exhibits a relationship with conditions such as multiple sclerosis and cardiovascular diseases. In the context of multiple sclerosis S1P1’s role in immune cell trafficking becomes especially relevant with its modulation affecting disease progression. In cardiovascular diseases S1P1 impacts endothelial function and vascular tone sometimes associating with proteins like eNOS. Modulation of S1P1 activity with therapeutic agents serves as an approach to manage some of these diseases highlighting its importance in medical research and treatment strategies.
