Description
Key facts
CAS number:444722-95-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:402.5 Da,
Molecular formula:C18H22N6O3S,
PubChem:4566,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine,
Biological description:Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects *in vivo.*,
Canonical smiles:C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N,
InChi:InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24),
InChiKey:OWXORKPNCHJYOF-UHFFFAOYSA-N,
IUPAC Name:4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
