Description
Key facts
CAS number:113760-29-5,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:273.4 Da,
Molecular formula:C15H15NO2S,
PubChem:13925917,
Nature:Synthetic,
Solubility:Soluble in DMSOSoluble in ethanol,
Biochemical name:1,3-Benzoxathiol-4(5H)-one, 6,7-dihydro-6,6-dimethyl-2-(phenylimino)-,
Biological description:Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC50 = 1.0 μM) and nitrite production (IC50 = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.,
Canonical smiles:CC1(CC2=C(C(=O)C1)SC(=NC3=CC=CC=C3)O2)C,
InChi:InChI=1S/C15H15NO2S/c1-15(2)8-11(17)13-12(9-15)18-14(19-13)16-10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,
InChiKey:XFSSJIQCIPSBHJ-UHFFFAOYSA-N,
IUPAC Name:6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months
