Description
Product details:
Elastic Stain Kit ab150667 uses a modified Verhoeff's Van Gieson / EVG stain to stain elastic fibers / elastin in tissue sections in histology. Staining of elastic tissue is useful in cases of emphysema (atrophy of elastic tissue), arteriosclerosis (thinning and loss of elastic fibers) and various other vascular diseases.
Other products for staining tissue sections
Find more kits and reagents in the
special stains guide
, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the
IHC kits and reagents guide
Staining Interpretation
Elastic fibers
Black to Blue/Black
Nuclei
Blue to Black
Collagen
Muscle & Other
Yellow
Control
Tissue:
Lung or any vascular tissue.
Other Notes
Please note, the 125 mL selling size, was previously described as 100 Test. There has been no change to the physical product.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Ambient
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Elastin also known as tropoelastin is an important protein in connective tissues contributing to the elasticity and flexibility of tissues like skin lungs and arteries. Elastin has a molecular weight of approximately 70 kDa. This protein is primarily expressed in organs that require elastic recoil for normal function. The highest concentrations of elastin can be found in elastic fibers which are critical components of the extracellular matrix of tissues like blood vessels lungs and skin. Elastin fibers can be visualized using specific staining techniques in histological studies such as elastin histology or elastic tissue stains.
Biological function summary
Elastin provides structural integrity and elasticity to connective tissues. It functions as a major component of elastic fibers which are complex structures formed in association with other proteins including fibrillin and microfibril-associated glycoproteins. These components work together to form a supportive mesh in the extracellular matrix. Elastin’s unique properties allow tissues to extend and return to their original shape maintaining tissue flexibility and resilience. Elastic fibers observed through various elastin staining methods help notice elastin’s distribution and organization within tissues.
Pathways
Elastin involves mainly in the extracellular matrix organization and the vascular smooth muscle contraction pathways. Elastin interacts with several proteins such as fibrillin-1 forming complex networks essential for maintaining vascular integrity and elasticity. Matrix metalloproteinases for instance play roles in the remodeling of the extracellular matrix involving elastin degradation and renewal processes. The regulation and interaction of these pathways are key to understanding how elastin supports normal tissue architecture and function.
Elastin associates with conditions like cutis laxa and Williams syndrome. Mutations in the elastin gene can lead to cutis laxa a disorder that affects the connective tissue causing loose saggy skin. Williams syndrome is linked to elastin gene deletions and affects cardiovascular connective tissue and neurodevelopmental aspects. These disorders highlight elastin's importance in maintaining healthy tissue structure and function. Associated proteins like fibrillin and lysyl oxidase contribute to understanding these conditions further linking elastin with broader connective tissue abnormalities.
