Description
Key facts
CAS number:755037-03-7,
Form:SolidSee storage information,
Molecular weight:482.8 Da,
Molecular formula:C21H15ClF4N4O3,
PubChem:11167602,
Nature:Synthetic,
Solubility:Soluble in DMSO (>50mg/ml)Slightly soluble in ethanol (1mg/ml)Insoluble in water,
Biochemical name:Regorafenib,
Biological description:Potent multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent for animal in vivo studies. Not suitable for human consumption.,
Canonical smiles:CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F,
InChi:InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32),
InChiKey:FNHKPVJBJVTLMP-UHFFFAOYSA-N,
IUPAC Name:4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions
