Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: Insertion of the selection cassette in exon 2,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-DENR, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Density Regulated Protein also known as NDRG1 is integral to various cellular processes. It weighs approximately 43 kDa and is encoded by the NDRG1 gene. This protein is widely expressed in many tissues including the liver brain heart and skeletal muscle. NDRG1 shows a specific functional expression in cells undergoing differentiation and stress responses. Researchers have identified its connection with the regulation of cell growth and proliferation leading to its descriptive name.
Biological function summary
Density Regulated Protein plays an important role in cellular stress responses and differentiation regulation. This protein interacts with various signaling molecules indicating its participation in larger protein complexes. It modulates the cell cycle and is involved in response to hypoxia. It also plays a critical role in inhibiting metastasis showing its importance in maintaining normal cell behavior and suppressing abnormal growth.
Pathways
NDRG1 integrates prominently within the PI3K/AKT signaling pathway. This pathway is essential for regulation of cell survival metabolism and growth. Within this context the protein interacts with and influences other proteins such as PTEN and mTOR which are key components of the pathway. Moreover it cross-talks with other pathways such as TGF-beta further highlighting its multifaceted roles in cellular dynamics.
Density Regulated Protein is linked to several conditions notably cancer and neurodegenerative diseases. In cancer its expression levels are often altered correlating with tumor suppression and metastasis inhibition. The interaction with p53 a well-known tumor suppressor protein illustrates the significance of NDRG1 in oncology research. Additionally malfunctions of this protein can lead to inherited conditions such as Charcot-Marie-Tooth disease suggesting its essential role in neurological health and integrity.
