Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 1 and 1 bp insertion in exon 1,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-GOLM2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CASC4 short for Cancer Susceptibility Candidate 4 is a protein involved in cell processes with a mass of approximately 87 kDa. It is expressed in various tissues with higher levels observed in specific cancer types. Its exact mechanical role in cells includes interactions and binding to other cellular elements influencing cell functions and stability. Researchers usually study this protein by its official name due to its relevance in cancer studies and its interaction potentials in cellular mechanisms.
Biological function summary
The protein plays a role in cellular growth and regulation. It is part of a larger complex that includes other signaling and structural proteins supporting its function in maintaining proper cellular environments. It may help ensure the cell cycle progresses smoothly influencing cell survival and replication. Its expression suggests it might help modulate responses under stress or during abnormal growth which can have implications for understanding certain cancer behaviors.
Pathways
CASC4 engages in cellular signaling and growth regulation pathways specifically those related to cancer biology. It is involved in pathways such as the PI3K/AKT pathway which is important for cell proliferation and survival. In these networks CASC4 connects with other proteins like AKT potentially influencing the pathway's outcomes on cell fate decisions and tumor progression. This interaction suggests that CASC4 may have a role in modifying signaling outcomes depending on different cellular contexts.
Research indicates that CASC4 is associated with cancer progression and certain subtypes like breast and colorectal cancers. These associations hint that abnormal expression or functioning of CASC4 could contribute to oncogenic processes. It often interacts with proteins like PTEN in these disease contexts emphasizing its potential impact on tumor suppression or promotion. Understanding these interactions could prove beneficial in developing targeted therapies or diagnostic markers for these cancers.
